منابع مشابه
DNA Helicases
DNA helicases are proteins that use the energy of NTP hydrolysis to processively denature duplex DNA.' As such, helicases can be considered similar to other mechanochemical motors that can catalyze directional movement along a polymeric lattice (e.g., microtubule-based motors as kinesin). Acting during DNA replication, helicases convert the duplex DNA to single strands and thereby activate the ...
متن کاملDna Helicases
In all organisms, genetic information is locked within a double helix formed by the two antiparallel deoxyribonucleic acid (DNA) strands. Although double-stranded DNA (dsDNA) is suitable for secure information storage, hydrogen bonds formed between complementary bases impair readout of this information by the cellular machineries that frequently require single-stranded DNA (ssDNA) as the templa...
متن کاملMechanisms and regulation of DNA end resection.
DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, because failure to repair these lesions can lead to genomic instability. DSBs can arise accidentally at unpredictable locations into the genome, but they are also normal intermediates in meiotic recombination. Moreover, the natural ends of linear chromosomes resemble DSBs. Although intrachromosomal DNA breaks are potent ...
متن کاملDNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.
The 5'-3' resection of DNA ends is a prerequisite for the repair of DNA double strand breaks by homologous recombination, microhomology-mediated end joining, and single strand annealing. Recent studies in yeast have shown that, following initial DNA end processing by the Mre11-Rad50-Xrs2 complex and Sae2, the extension of resection tracts is mediated either by exonuclease 1 or by combined activ...
متن کاملDNA End Resection: Facts and Mechanisms
DNA double-strand breaks (DSBs), which arise following exposure to a number of endogenous and exogenous agents, can be repaired by either the homologous recombination (HR) or non-homologous end-joining (NHEJ) pathways in eukaryotic cells. A vital step in HR repair is DNA end resection, which generates a long 3' single-stranded DNA (ssDNA) tail that can invade the homologous DNA strand. The gene...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.2446